The Ilanges lab is interested in understanding the role of the nervous system in controlling our physiological state. We are especially interested in how the nervous system can coordinate dramatic shifts in aspects of behavior, autonomic function, and metabolism during adaptive states such as our response to infection, termed sickness. To accomplish this, we use a combination of molecular and systems level approaches in both mice and zebrafish. The lab is looking for a Postdoctoral Scientist with interest in neuroimmune interactions, molecular to circuit level dissection of circuits in the nervous system, neuronal control of organ function, or whole-body metabolism. The lab has ongoing projects exploring different aspects of physiology regulation with a foundation in neuroscience approaches and aided by organ function and metabolic phenotyping. Candidates with experience in molecular biology, neuronal manipulations and imaging, immunology, metabolic phenotyping (e.g. metabolomics), and electrophysiology are particularly encouraged to apply. The lab is part of the 4D Cellular Physiology (4DCP) research area at Janelia Research Campus, a broad and collaborative group focused on general principles of cell and tissue organization across systems and how the nervous system communicates with these diverse peripheral systems to coordinate bodily function. Responsibilities include handling two or more independent or collaborative research projects studying the nervous system's role in controlling diverse aspects of physiology, particularly in the infection induced sickness state; developing and testing hypotheses to probe brain-body communication across scales in mice, with potential work in zebrafish; in vivo two photon imaging and neuronal manipulations with opto- and chemogenetic tools; phenotyping function at the level of individual organs, metabolism using indirect calorimetry and metabolomics, and behavior; whole mount tissue clearing and imaging; single cell RNA sequencing and single cell ATAC sequencing; stereotactic and other forms of surgery. Requirements include a Ph.D. in biology (neuroscience, molecular biology, immunology, metabolism, or related fields), strong initiative, self-motivation, capacity for creative problem solving, strong verbal and written communication skills, and willingness to work collaboratively in a small lab environment. Physical requirements include ability to remain seated or standing for extended periods, dexterity to manipulate objects, communication skills, and mobility to move materials weighing up to several pounds. Persons with disabilities may request reasonable accommodation. The job description is not exhaustive and essential functions are defined by the Americans with Disabilities Act.
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